Walking along the oldest human fossil pathway (Roccamonfina volcano, Central Italy)?

Here we report the remarkable superposition of a pre-historic trackway (349–350 ± 3 ka) with one used in more recent historical times, potentially forming one of the oldest path or trackways currently known. A Plinian eruption of the Roccamonfina Volcano resulted in a succession of pyroclastic flows. A combination of syn-sedimentary erosion and depositional morphology resulted in a bench, contouring the depositional slope. Prior to rapid lithification of the flow, early human ancestors used the bench as a route-way. At least two individuals diverted from this route-way to make the famous Trackways A and B of the Devil's Trails which have been described previously. The bench and associated animal tracks were covered by subsequent pyroclastic ash falls before being exhumed in historical times by a combination of natural erosion and quarrying. The bench was re-used as a route-way at this time and some of the tracks modified by human action to improve surface conditions and perhaps drainage. The P1-Trackway is the result and its detailed morphology is described here. Not only does it provide remarkable evidence of the convergence of route-ways through time along key geomorphological features in the landscape but the palimpsest of tracks provides a useful case study for archaeologists and ichnologists interpreting complex and superimposed surface traces

Chemostratigraphy of the Pliensbachian, Puesto Araya Formation (Neuquén Basin, Argentina)

In a preliminary attempt to establish an isotope stratigraphy, strontium, carbon and oxygen isotope ratios were determined from marine biogenic carbonates of Pliensbachian age, in the context of scheme of local ammonite Zones correlatable to the European Standard Zonation. Two sections, rio Atuel and arroyo Serrucho, of the mainly siliciclastic Puesto Araya Formation, Neuquen Basin, south-western Mendoza, Argentina, were studied. Specimens of the bivalve genera Weyla Bhom and Gryphaea Lamarck were selected for the isotopic determinations because of their low-Mg calcite original mineralogy and widespread presence. Scanning electron microscopy, X-ray diffraction and X-ray fluorescence spectrometry techniques were used to control the good degree of preservation of most of the biogenic material, as evidenced by pristine fabrics, 100% calcite composition and Sr, Mn and Fe concentrations. Although strontium isotope ratios are slightly scattered, it is possible to compare them with those of the Early Jurassic seawater reference curve. Carbon isotope signals show two relative maxima, correlatable with those recorded for the upper part of the Ibex Zone and the middle part of the Margaritatus Zone in various European sections, indicating the possible global significance of these events. δ18O values were found to be unreliable for isotope stratigraphy, as they are largely depleted in comparison to those of coeval unaltered marine carbonates

MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity

Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneit

MEIOTIC ORIGIN OF TRISOMY IN NEOPLASM: EVIDENCE IN A CASE OF ERYTROLEUKAEMIA

Trisomic cells in neoplasms may represent abnormal clones originated from a tissue-confined mosaicism, and arise therefore by a meiotic error. We report on a 16-month-old child with erythroleukaemia (AML-M6), whose marrow karyotype at onset was 48,XX,del(13)(q12q14),del(14)(q22q32),+21,+21. The parental origin of the supernumerary chromosomes 21 was investigated by comparing 10 polymorphic loci scattered along the whole chromosome on the patient's marrow and her parents' leukocytes. Three loci were informative for the presence of three alleles, two of which were of maternal origin; two further loci showed a maternal allele of higher intensity. Lymphocytes and skin fibroblasts showed a normal karyotype, and molecular analysis on leukocytes at remission, buccal smear and urinary sediment cells consistently showed only one maternal allele, whereas neonatal blood from Guthrie spot showed two maternal alleles as in the marrow. An accurate clinical re-evaluation confirmed a normal phenotype. Our results indicate that tetrasomy 21 arose from a marrow clone with trisomy 21 of meiotic origin. To the best of our knowledge, this is the first evidence that supernumerary chromosomes in neoplastic clones may in fact be present due to a meiotic error. This demonstrates that a tissue-confined constitutional mosaicism for a trisomy may indeed represent the first event in multistep carcinogenesis

El recurso Solanum tuberosum y la reconstrucción paleodietaria humana en la ecorregión de Puna (provincia de Jujuy, Argentina)

El objetivo general de este trabajo fue generar datos para el armado de un marco de referencia adecuado para el estudio paleodietario humano, mediante el análisis de isótopos estables, en la ecorregión de Puna, Noroeste argentino. Con tal fin, se presentan los primeros resultados del análisis isótopos estables del carbono y el nitrógeno (δ13C y δ15N) en vegetales, principalmente Solanum tuberosum (n = 24). Los especímenes se adquirieron en el mercado local y en huertas familiares, estas últimas sin recibir ni abonos ni plaguicidas sintéticos, los cuales pueden incidir en las relaciones isotópicas del nitrógeno. La metodología propuesta consistió en el relevamiento de información entre productores locales, la caracterización del suelo en cuanto a sus propiedades químicas (PH, conductividad eléctrica, carbono orgánico y nitratos) y la medición isotópica de los vegetales muestreados. Los datos obtenidos demuestran una escasa variación en los valores δ15N, aunque tres especímenes de la variedad Desirée presentan valores llamativamente altos (entre +13,5 ‰ y +15,2 ‰)

Active window management: Reducing energy consumption of TCP congestion control

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Chemostratigraphy of the Pliensbachian, Puesto Araya Formation (Neuquén Basin, Argentina)

In a preliminary attempt to establish an isotope stratigraphy, strontium, carbon and oxygen isotope ratios were determined from marine biogenic carbonates of Pliensbachian age, in the context of scheme of local ammonite Zones correlatable to the European Standard Zonation. Two sections, río Atuel and arroyo Serrucho, of the mainly siliciclastic Puesto Araya Formation, Neuquén Basin, south-western Mendoza, Argentina, were studied. Specimens of the bivalve genera Weyla Bhöm and Gryphaea Lamarck were selected for the isotopic determinations because of their low-Mg calcite original mineralogy and widespread presence. Scanning electron microscopy, X-ray diffraction and X-ray fluorescence spectrometry techniques were used to control the good degree of preservation of most of the biogenic material, as evidenced by pristine fabrics, 100% calcite composition and Sr, Mn and Fe concentrations. Although strontium isotope ratios are slightly scattered, it is possible to compare them with those of the Early Jurassic seawater reference curve. Carbon isotope signals show two relative maxima, correlatable with those recorded for the upper part of the Ibex Zone and the middle part of the Margaritatus Zone in various European sections, indicating the possible global significance of these events. d18O values were found to be unreliable for isotope stratigraphy, as they are largely depleted in comparison to those of coeval unaltered marine carbonates.Universidad de Buenos AiresFacultad de Ciencias Naturales y Muse

Stable Isotope Analysis of the Inca Mummy from Nevado de Chuscha (Salta, Argentina)

This paper presents the carbon (13C/12C), nitrogen (15N/14N), oxygen (18O/16O), hydrogen (2H/1H) and sulfur (34S/32S) stable isotope values measured in the hair of a female individual from north-western Argentina. The analysis of segments of this tissue allows for the recording of the diet and migratory changes with a short time resolution. The sample is from a mummified young female individual discovered in Chuscha mount, Salta province. It was found at more than 5000 masl, in a mountain sanctuary of the Inca expansion (capacochas). The paper discusses the paleodiet and mobility patterns of this individual in the period before her death, focusing on the isotopic variations in a limited time scale. The results indicate that the individual moved from a different region to the place where she was sacrificed. Furthermore, in the last year the individual was alive, a shift in the isotopic composition of the food consumed is detected: a variation in the importance of C4 over C3 resources is evident. The results are compared with the isotopic estimations for other children and young people recovered in archaeological contexts associated with capacochas to infer variability in the geographical trajectories covered during their last months of life.Fil: Killian Galván, Violeta Anahí. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto Interdisciplinario Tilcara; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tessone, Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geocronología y Geología Isotópica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geocronología y Geología Isotópica; ArgentinaFil: Valenzuela, Luciano Oscar. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Sociales. Departamento de Arqueología. Laboratorio de Ecología Evolutiva Humana (Sede Quequén); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sharp, Z. D.. Universidad de Nuevo México.; Estados UnidosFil: Panarello, Hector Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geocronología y Geología Isotópica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geocronología y Geología Isotópica; Argentin